The number of fasteners used in aircraft is vast, reaching millions. Aluminum alloy wire for fasteners has become a focus of research. In this study, the Al-Zn-Mg-Cu alloy wire was prepared by hot rolling and extruding methods. A comparative analysis of microstructure and mechanical properties was examined. Results indicated that the hot rolling technique yields a more homogeneous microstructure and enhances the stability of mechanical properties. Following solution treatment and aging, a significant quantity of nano-sized strengthening η′ phases developed within the alloy. This led to improvements in both strength and elongation relative to the cold-deformed state. Consequently, the hot rolling method emerges as the most effective approach for the industrial production of alloy wire for fasteners.